AFL 21-24 From the California Department of Public Health
July 22, 2021
TO: General Acute Care Hospitals
Acute Psychiatric Hospitals
SUBJECT:Call for Specimens from Hospitalized Coronavirus Disease 2019 (COVID-19) Patients
All Facilities Letter (AFL) Summary
This AFL announces a request that facilities submit respiratory and/or serum specimens from hospitalized COVID-19 patients to assist the state in tracking COVID-19 variants. Specimens can be submitted to your local public health laboratory or to California Department of Public Health’s (CDPH) Viral and Rickettsial Disease Laboratory (VRDL).
Over the course of the COVID-19 pandemic, there have been additional variants of the SARS-CoV-2 virus that causes COVID-19 identified in California. While there is much to be learned about these variants, evidence continues to grow that virus mutations can affect transmission, diagnostics, therapeutics, clinical outcome, and immune escape. There is growing concern that certain variants may be responsible for more severe disease as well there is concern for potential vaccine escape, thus increasing the chance for post-vaccination infection.
As capacity for whole genome sequencing (WGS) increases, CDPH is putting out a call to all healthcare providers in the state to submit respiratory specimens for WGS and serum specimens to measure antibody response from hospitalized COVD-19 patients. Please review the attached guidance for additional information.
Please contact your local public health laboratory for submittal instructions. For additional questions or questions pertaining to submission of serum specimens, please contact CDPH VRDL at VRDL.Mail@cdph.ca.gov or 510-310-8585.
Original signed by Cassie Dunham
Acting Deputy Director
 For local health jurisdictions recommending specimen submission directly to VRDL, providers should review the VRDL specimen shipping guidelines webpage and complete a General Purpose Specimen Submittal Form (PDF)